Will develop treatment against ‘accelerated Alzheimer’s’ effect of Covid-19


Özlem YURTÇU KARABULUT, Kubilay ÖZEV / Istanbul, (DHA) | Wednesday, June 16, 2021 – 17:47 | Last Updated : 16 06 2021 – 17:47

Neurosurgeon, who works on the neurological effects of HIV at the Scripps Institute in California, one of the most prestigious research centers in the world. Dr. Murat Digiçaylıoğlu made important statements to DHA regarding the research started on the short and long-term neurological damage of Covid-19. prof. Dr. Explaining that an “accelerated Alzheimer’s type” develops in HIV patients in the long term, and that the same risk exists in Covid-19, Digiçaylıoğlu said, “We aim to prevent or regress this with therapies to be obtained with mRNA technology used in Covid vaccines.”

Neurosurgeon Prof. Dr. Murat Digiçaylıoğlu completed his doctorate in Switzerland after receiving his medical education at Ruhr University in Germany. Later, he went to America and worked at Harvard Medical School for a while.

Announcing his name to the whole world with his 9-page work in the world-famous scientific journal ‘Nature’ with his invention that prevents the cells in the brain from dying after a brain hemorrhage, Prof. Dr. Murat Digiçaylıoğlu still conducts his research at the Scripps Institute in California.

In his laboratory at the Scripps Institute, where many important scientists, some Nobel laureates, work in the fields of synthetic chemistry, immunology, molecular biology and biophysics, he conducts studies examining the effects of nutrition, especially in the treatment of neurological damage caused by HIV and glioblastoma, an aggressive brain tumor.

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prof. Dr. Digiçaylıoğlu’s new project is research on the Covid-19 virus. Stating that their application to the “Neurological Disorders and Stroke” unit (NINDS) of the American National Institute of Health about 5 months ago was accepted last week, Prof. Dr. Digiçaylıoğlu explained the details of the study. prof. Dr. Digiçaylıoğlu pointed out that coronavirus is a disease caused by a virus like HIV, and said that it may lead to similar pictures in terms of neurological effects, especially in the long term.

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“VIRUS CAUSES ACCELERATED ALZHEIMER IN THE BRAIN”

prof. Dr. Digiçaylıoğlu said, “We continue our work at the Scripps Institute on the short- and long-term neurological effects of HIV. Similarly, we started to work on the short- and long-term neurological effects of Covid-19. There are similarities between the two in terms of neurological effects. HIV is now It has become a chronic disease. Patients can live longer with treatments, but we have seen that this time, some long-term neurological damage may occur in HIV-positive individuals. The reason for this is currently unknown. We are trying to understand this with our studies. We have already begun to see these effects. Thinking 5-10 years from now, we have started these studies on Kovid. Both HIV and Covid-19 are diseases based on viruses in origin. The common point of both is ‘neuronal inflammation’ in the brain. Kovid has only been in our lives for 1.5 years, it is a very young disease, statistically We don’t have definitive long-term data yet. But the data we already have shows that some neurological problems develop in patients who have experienced Covid-19 symptomatically. Serious damage can occur. One of the most important of these is the lack of memory and perception, the weakening of the brain capacity. The neurological damage we see in both HIV and Covid is very similar to Alzheimer’s. In fact, these two diseases cause an ‘accelerated Alzheimer’s,’ he said.

HUMAN CELLS WILL BE USED IN $1.6 MILLION RESEARCH

prof. Dr. Digiçaylıoğlu explained that NINDS gave them a fund of 1 million 592 thousand dollars for the study and gave the following information:

“1 million 592 thousand dollars have been supported by the NINDS unit of the US Department of Health. We are conducting this study together with my friend, basic scientist (psychology) Marc Shaphiro from the University of Texas. Animal Covid-19 is not a good model for this research, unfortunately. O Therefore, we are trying to see the damage that the original and genetically modified S1 hook (Spike protein) of the virus causes or can cause in the cells, using cells obtained from human biopsies. It causes the blood barrier, which should function, not be able to perform its function. In this way, various substances that should not enter the brain enter the brain uncontrollably, which triggers neuroinflammation. It makes the picture more severe. In a second stage, microglia (immune system cells of the brain) entering the brain uncontrollably increases and fuels inflammation even more.”

“THE mRNA TECHNOLOGY FOLLOWING CAN ALSO BE USED FOR THE TREATMENT”

Stating that the project will take 5 years, Prof. Dr. Digiçaylıoğlu concluded his words as follows:

“We will see general cellular mechanisms in the first year. In other words, which signaling mechanisms damage the brain-blood barrier, how the S1 hook damages the endothelial cells there, in a sense, we will see the conversations and communication within the cell. After revealing it, if we balance the brain-blood barrier in volunteer patients who have had covid. or if we fix it, we will see if the damage caused by the S1 hook is reduced, whether it can be reversed. To do this, we will do it by using the technology, the logic of which the covid vaccines are developed. In other words, we will either prevent or reverse the damage caused by the S1 spike protein to the brain blood barrier, by using mRNA technology. “We are aiming to use Messenger RNA, that is, mRNA, in a way that prevents the blood-brain barrier from being weak against the virus. As a result, mRNA technology can be used not only as a covid vaccine, that is, to prevent the disease, but also as a treatment for the neurological diseases caused by COVID.”